| abstract |
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an <i>N</i>-oxide form thereof or a pharma-ceutically acceptable acid addition salt thereof, wherein -a<1>=a<2>-a<3>=a<4>- is a bivalent radical wherein one or two of a<1> to a<4> are nitrogen and the remaining a<1> to a<4> are -CH=; -Z<1>-Z<2>- is a bivalent radical; -A- is a bivalent radical of formula -N(R<6>)-Alk<2>- or a 5, 6 or 7-membered saturated heterocycle containing one or two nitrogen atoms; R<1>, R<2> and R<3> are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; Alk<1> and Alk<2> are optionally substituted C1-6alkanediyl; R<5> is a radical of formula (d-1), (d-2), (d-3), (d-4), (d-5) wherein n is 1 or 2; p<1> is 0, and p<2> is 1 or 2; or p<1> is 1 or 2, and p<2> is 0; X is oxygen, sulfur or =NR<9>; Y<2> is oxygen or sulfur; R<7> is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R<8> is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R<9> is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R<10> is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to disturbed fundic accomodation. |