| abstract |
The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)<SUB>2</SUB>, or NR<SUP>6</SUP> where R<SUP>6</SUP> is hydrogen or C<SUB>1-6</SUB>alkyl; R<SUP>5</SUP> is an optionally substituted 5-membered heteroaromatic ring, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP> are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed. |