http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-20021340-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8ec35c2549b36b67e202b24d68d7193 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-14 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-02 |
| filingDate | 2000-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_150893547d7ae20fd7653d69820df04b |
| publicationDate | 2002-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-20021340-A3 |
| titleOfInvention | Methods of asymmetrically preparing the enantiomers of acylanilides, derivatives thereof and intermediates for said preparations |
| abstract | A method of synthesizing pure enantiomers of acylanalides such as Casodex3 (bicalutamide) and its derivatives includes contacting a compound having a ring structure that, when opened, provides a substituent having the structure of Formula (I), with a compound having a structure of the Formula (II): R<7>-R<6>-X<1>H, under conditions sufficient to provide a compound having the structure of Formula (III) wherein X<2> is oxygen, sulfur, sulphinyl (-SO-), sulphonyl (-SO2-), imino (-NH-), oxidized imino alkylimino (-NR<8>-) where R<8> is alkyl having up to 6 carbon atoms, or oxidized alkylimino. The method further includes treating the compound of Formula (III) under conditions sufficient to provide a pure enantiomer of acylanalides such as Casodex3 (bicalutamide) and/or derivatives thereof. In preferred embodiments, R<1> is methyl, R<2> is methylene, R<6> is a direct link, R<7> is 4-fluorophenyl, X<1> is sulfur, the compound of Formula (II) is 4-fluorobenzenethiol, and X<2> is sulphonyl. Methods of synthesizing acylanalides such as Casodex3 (bicalutamide) and/or derivatives thereof from a starting material of citramalic acid are also provided. |
| priorityDate | 1999-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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