| abstract |
The use of oxa or thiazolidinone derivs. of formula (I) and their optical isomers and salts for the treatment of ulcers or angina is new. In (I), W = S or O and X = NR3; or X = S or O and W = NR3; R3 = H, 1-6 C alkyl or aryl-1-4 C alkyl; R4, R5 = H, 1-6 C alkyl, aryl 1-4 C alkyl, or phenyl or Het both opt. substd. by 1-6 C alkyl, NH2 or mono- or di- 1-6 C alkylamino; Het = 5-6 membered heterocyclyl contg. 1-3 O, N or S; R6 = H, 1-6 C alkyl or aryl 1-4 C alkyl; A = 2-6 C alkylene opt. substd. by carboxy, 1-6 C alkoxycarbonyl, or aryloxycarbonyl; aryl = 6-10 C aryl opt. substd. by 1-6 C alkyl, 1-6 C alkoxy, OH, halo, NH2 or mono- or di- 1-6 C alkylamino. |