| abstract |
The invention provides compounds of general formula (I) wherein: R<1> represents optionally substituted C1-C12 alkyl or optionally substituted 3- to 10-membered saturated or unsaturated ring system comprising up to two ring carbon atoms that form carbonyl groups and comprising up to 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur; m is 0-1; Q represents OCH2, C1-C4 alkylene or C2-C4 alkenylene; T represents C(O)NH, or when m is 0, T may additionally represent a bond or NH, or when m is 1 and Q represents C1-C4 alkylene, T may additionally represent NH; n is 1-4; each R<2> and R<3> independently represents H or C1-C4 alkyl; V represents N, and W represents N or CH; X represents O, C(O), CH(OH), SO2, NH or N(C1-C6 alkyl), provided that when W represents N, then X represents either C(O) or SO2 and when W represents CH, then X is other than SO2; R<4> represents optionally substituted phenyl; R<5> and R<6> each independently represent H, C1-C6 alkyl or hydroxyC1-C6 alkyl, or R<5> and R<6> together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R<7> and R<8> each independently represent H or C1-C6 alkyl; and R<9> represents OH or -NR<7>R<8>; processes for their preparation, pharmaceutical compositions containing them and their use in therapy. |