http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-2001241-A3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36089addd8e49e968b4c7e13c517dd1c |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
filingDate | 1999-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d361383c0cfb3f7d0753d17dc2626765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc3a347e4d826fa30c89b199ad15b6e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36422632585f56f67c527c279ae30292 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f40ca240ab5fd77b179f9fde6bc73c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb7db50e02d72bec0575458c08f5d610 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cc78da8bc4050449b2b46d92b69c8e9 |
publicationDate | 2001-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CZ-2001241-A3 |
titleOfInvention | Phthalazine derivatives |
abstract | The phthalazine derivative of formula (I); Z is NH, methylene, an alkylene chain which is optionally branched and / or unsaturated and / or interrupted by a (C5-C7) cycloalkyl residue; A is phenyl or heterocycle optionally substituted with one or more substituents selected from oxo, nitro, carboxy and halogen, or COR 4; R represents an alkyl or polyfluoroalkyl group; R 1 is absent when it is a double bond, or when a single bond represents a) a hydrogen atom; b) alkyl optionally substituted with aryl, heterocycle or COR 5; c) -CORO; d) alkylsulfonyl; R 2 represents two hydrogen atoms or = O, wherein -— is a single bond, or if -I is a double bond, R 2 is hydrogen, cyano, alkoxycarbonyl, amido, optionally substituted aryl or heterocycle, alkyl, alkenyl or alkynyl or branched and / or substituted; R 3 is hydrogen, or and alkyl, alkenyl or alkynyl optionally substituted with hydroxy, oxo, aryl or heterocycle, and optionally interrupted by one or more heteroatoms or one or more hetero groups; N? Derivatives of the compounds of formula I and pharmaceutically acceptable salts thereof. Also described are pharmaceutical compositions containing these compounds and the use of compounds as PDE 4 inhibitors. |
priorityDate | 1999-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 530.