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filingDate 1999-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f02079e28c7dd23762cbfe7bfdb0f95
publicationDate 2001-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-20012140-A3
titleOfInvention A method for preparing a fizzy gluconate-containing granulate, a granulate obtained in this manner, and tablets containing the granulate
abstract A method for preparing an effervescent granulate comprising ferrous gluconate as pharmacologically active ingredient, and citric acid and sodium bicarbonate as effervescent system, by means of wet granulation in a fluid-bed granulator, wherein the said method comprises the steps of I) feeding a mixture comprising ferrous gluconate, citric acid and sodium bicarbonate into the said granulator which is simultaneously fed with a flow of air heated to about 70 DEG C and having a moisture content of <1.0 g/kg; II) wetting the said mixture with nebulized water when this mixture has reached a temperature of about 35 DEG C; III) evaporating off the nebulizing water, while keeping the temperature of the said mixture substantially constant at 35 DEG C; IV) repeating steps II and III until a granulate with the desired features is obtained; and V) drying the said granulate with air heated to about 80 DEG C until its moisture content is </=0.5 % by weight. Granulate thus obtained and tablets containing the same.
priorityDate 1998-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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