http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-20011760-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1999-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_035b0092d4a68148bc295a96d1d96a11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39ec844ff2ac45e545ef146d0f3cfc2b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ecd08f64d15c2746d7aed869f9a47a7 |
| publicationDate | 2001-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-20011760-A3 |
| titleOfInvention | Pyrrolidine derivatives as CCR-3 receptor antagonists |
| abstract | This invention relates to certain 3-aminomethylpyrrolidine derivatives of Formula (I), wherein: Z is -N- or -(N<+>r)- X<-> wherein R is alkyl, haloalkyl, aralkyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, or cyanoalkyl, and X<-> is a pharmaceutically acceptable counterion; Ar<1> and Ar<2> are, independently of each other, aryl or heteroaryl; Q is straight or branched alkylene with 1-3 carbon atoms; R<1> is hydrogen or alkyl; A is either: (I) -N(R<2>)C(O)- when: B is: (i) an alkylene with 1-4 carbon atoms inclusive wherein one of the carbon atoms may optionally be replaced by a group selected from -C(O)-, -N(R<4>)-, -O-, -S(O)n- (where n is 0, 1 or 2), -NR<5>C(O)- and -N(R<6>)SO2-; or (ii) an alkynylene chain; or (II) a group selected from -N(R<2>)C(S)-, -N(R<2>)C(O)N(R<3>)-, -N(R<2>)C(S)N(R<3>)-, -N(R<2>)SO2-, -N(R<2>)SO2N(R<3>)-, -N(R<2>)C(O)O-, and -OC(O)N(R<3>)- when: B is: (i) a bond; (ii) an alkylene chain of 1-4 carbon atoms inclusive wherein one of the carbon atoms may optionally be replaced by a group selected from -C(O)-, -N(R<4>)-, -O-, -S(O)n- (where n is 0, 1 or 2), -NR<5>C(O)- and -N(R<6>)SO2-; (iii) an alkenylene chain; or (iv) an alkynylene chain; that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds. |
| priorityDate | 1998-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 358.