| abstract |
The novel compounds of formula I wherein the bond is depictednthe dashed line may be single, double, or non-brokennand if the bond is absent, then nitrogen isnsubstituted with hydrogen and R2; Xnrepresents SO 2, C = O or CH 2; Y represents -CH (R4) -, -nN (R 4) - or -N (R 4) -CH 2 -, O; and the other substituents R 2, R 3, R 4,nR 5, R 6, R 7 and R 8 are of particular significance. The compounds areneffective as positive AMPA receptor modulators, for examplenin the treatment of memory or learning disorders, psychotic disorders,nsexual dysfunction, intellectual disorders, schizophrenia,ndepression or autism. |