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publicationDate 2001-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-20002858-A3
titleOfInvention Pharmaceutical compositions based on controlled release pellets of high active ingredient potassium chloride
abstract The invention relates to controlled release multi-dosage pharmaceutical composition in solid oral form, preferably in the form of tablets or hard gelatine capsules and having a potassium chloride content of 500-1000 mg per dosage unit characterized by a content of at least 70 % by weight of potassium chloride, in the form of coated or partially uncoated pellets. The tablets or hard gelatine capsules according to the present invention are comprising pellets which contain at least 70 % by weight of potassium chloride, 10-25 % by weight of microcrystalline cellulose, 0.1-0.5 % by weight of an anti-adhesion agent and 0.1-5.0 % by weight of a hydrophobizing agent; a coating layer applied onto said pellets comprising 3-10 % by weight of an ethyl acrylate/methyl methacrylate copolymer and/or an ammonium methacrylate copolymer, a hydrophobizing agent, talc and optionally a dye; and optionally potassium chloride particles and further auxiliary agents applied onto said layer.
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