http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-2000275-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634715a790f7ef0163a61e9f364bebcd |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-24 |
| filingDate | 1998-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_434b354b9f3c182e8d4c6fd0be1e56dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7448b92ab8a6d703d7cc6bb9eda9dfa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa9c3507a41ffcb4ac5e44bda87b3d11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bff00b0b4af040e94244bec19e15210 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5c897e41dbc22a06a317666720cbb13 |
| publicationDate | 2000-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-2000275-A3 |
| titleOfInvention | Substituted 1,2,2,4-tetrahydronaphthalene derivatives |
| abstract | The present invention relates to novel 1,2,3,4-tetrahydronaphthalenesnderivatives substituted with piperidyl or piperazinyl,nhaving the general formula I wherein X is N or CH, Y isnNR2CH2, CH2-NR2, NR2-CO, CO-NR2 or NR2-SO2, where R2nis H or an alkyl group having 1 to 6 carbon atoms, R 1 is H,nalkyl or cycloalkyl, R 3 is alkyl,ncycloalkyl or (CH 2) n -aryl wherein aryl is phenylnor a heteroaromatic ring containing 1 or 2 heteroatomsnselected from N, O and S, and which may be mono- orndisubstituted, n is 0 to 4, R 9 is alkyl,ncycloalkyl, OCF 3, OCHF 2, OCH 2 F, halogen, CN,nCF 3, OH, alkoxy, alkoxyalkyl, NRJU,nSO 3 CH 3, SO 3 CF 3, SO 2 NR 6 R 7, unsubstituted ornsubstituted heterocyclic or heteroaromatic ringncontaining 1 or 2 heteroatoms selected from N and O, wherenthe substituents are alkyl or COR 9, wherein R 8, R 7 andnR 5 is as defined above, as (R) -enantiomers,n(S) enantiomers or racemates in the form of the free base ornpharmaceutically acceptable salts thereof;npharmaceutical compositions comprising said therapeuticallynactive compounds and the use of said compounds in the treatment,nas h5-HT1B antagonists. |
| priorityDate | 1998-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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