| abstract |
Certain compounds within formula (I) are inhibitors of platelet aggregation wherein A<1> is NH or CH<2>; R is H, C1-6alkyl, benzyl or a carboxy protecting group; R<3> is C1-6alkyl, Ar- C0-6alkyl, C1-6cycloalkyl C0-6alkyl, or Het C0-6alkyl; R<6> is 4-amidino-Ar-N(CH3)CO, [[2-(4-piperidinyl)ethyl] (N-methyl)amino] carbonyl, (4,4'-bipiperidin-1-yl) carbonyl, [4-(2-aminoethyl) piperidin-1-yl]carbonyl, [[[3-(4-piperidinyl] propyl]methylamino]carbonyl, 1-[4- (4-pyridyl)piperazinyl]carbonyl, [[2-[(2-amino)pyrid -4-yl]ethyl]methylamino] carbonyl, [[2-(4-piperidinyl) ethyl]carbonyl]amino, [[2-(4-piperidinyl) ethyl]carbonyl]amino, [[2-(1-piperazinyl) ethyl]methylamino] -carbonyl, or [[(1,2,3,4- tetrahydro-7-isoquinolinyl] amino] carbonyl; and X is H, C1-4alkyl, C1-4 alkoxy, C1-4 alkthio, trifluoroalkyl, N(R')2, CO2R', CON(R')2, OH, F, Cl, Br or I. |