http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-191398-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-0076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1996-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c4e870f8d0aa1f05a645740ad5fe797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be4a92bab913e8b38fa87509d9e333d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b885a86aa5d3b86d012c5174210e29f |
| publicationDate | 1998-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-191398-A3 |
| titleOfInvention | Process for preparing 9,11β-epoxisteroids |
| abstract | Disclosed is a process for producing the epoxy steroid (1.0) wherein R<1> is selected from H, -OH, or C1, and R<2> is selected from hydrogen or lower alkyl. The process comprises reacting the triene of Formula (2.0) with a brominating or chlorinating agent in DMF containing a catalytic amount of 70 % HC1O4, at a temperature of about 0 to about +40 DEG C to produce the corresponding bromoformate (3.0) or chloroformate (3.0A) wherein when R<1> is H then R<3> is H; and when R<1> is -OH then R<3> is a suitably protected -OH group; and when R<1> is C1 then R<3> is C1. The bromoformate or chloroformate is then reacted, at a temperature of about -20 to about +10 DEG C, with a strong base in an organic solvent mixture comprising: (a) THF or CH2C12 and (b) a C1 to C6 alkanol or acetonitrile, to produce the epoxy steroid (1.0). |
| priorityDate | 1995-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.