| abstract |
The invention relates to a process for the preparation of polymeric Lewis X saccharides of the formula <IMAGE> in which X is OC(=NH)CCl3 (TCAl), Z or S, Z is OCH2CH(NHCOCuH2u+1)CH(OH)CH=CHCvH2v+1, S is (CH2)qCOOR'', R is OH, R<sg>, R<sg> is OAc, OBn or OBz, R' is OH, OAc or OPiv, R'' is C1 to C4-alkyl, Ac is acetyl, Bn is benzyl, Bz is benzoyl, Piv is pivaloyl, n is an integer from 0 to 7, q is an integer from 4 to 12, u is an integer from 13 to 23, and v is an integer from 11 to 17, to a process for preparing appropriate intermediates, and to polar Lewis X saccharides, especially tetrameric to octameric Lewis X antigen. The polymeric saccharides can be synthesised stereoselectively in high yields. |