| abstract |
There are described N-(tetrahydropyran-4-yloxyalkanoyl)staurosporin derivatives of the formula I <IMAGE> in which R1 is hydrogen, hydroxyl, lower alkoxy or oxo, R2 is hydrogen or C1-4-alkyl and R3 is hydrogen or C1-4-alkyl, a process and novel intermediates for their preparation and a process for the preparation of the intermediates. The compounds of the formula I inhibit the enzyme protein kinase C with a high degree of selectivity and can be used, in particular, as antitumour active compounds. |