| abstract |
The present invention relates to substituted isothiazole [5,4-b] pyridine-2-carboxamides of formula I, wherein R1, R2, R3, R10, R11 and X are as defined in the claims. The compounds of formula I are transglutaminase inhibitors, in particular transglutaminase 2 (TGM2), and are suitable for the treatment of various diseases, for example degenerative joint diseases such as osteoarthritis. The invention further relates to processes for the preparation of the compounds of formula (I), their use as pharmaceuticals, and pharmaceutical compositions containing them. |