abstract |
The present invention relates to an improved process for the production of naltrexone [17- (cyclopropylmethyl) -4,5α-epoxy-3,14-dihydroxy-morphinan-6-one] from norexymorphon [4,5-α-epoxy- 3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide. |