| abstract |
Disclosed: compound represented by the general formula (I); and others. (I) wherein A1 and A2 represent independently a nitrogen atom or a methine group which may be substituted; ring B represents a 5- to 7- membered aliphatic ring or a spiral or bicyclic ring formed by the aliphatic ring and a 3- to 7-membered aliphatic ring other than the aforementioned aliphatic ring; R 1 represents a hydrogen atom, a C 1 -C 6 alkyl group which may be substituted or an aryl, aralkyl, or heteroaryl group; can be u substituted; R 2 represents an aryl, aralkyl or heteroaryl group which may be substituted; and X represents a group represented by the formula = NH or = O. The compound has excellent cell proliferation inhibition activity based on a Wee1 kinase inhibition activity and an additive / synergistic effect with another anti-cancer agent, and is therefore useful in the medical field. |