| abstract |
This invention relates to a novel substituted 5- (1-benzothiophen-2-yl) pyrrolo [2,1-f] [1,2,4] triazin-4-amine derivative of formula (I) wherein R1 is hydrogen , chlorine, methyl or methoxy, R 2 is hydrogen or methoxy, provided that at least one of R 1 and R 2 is other than hydrogen, G 1 is chlorine, (C 1 -C 4) -alkyl, (C 1 -C 4) - alkoxycarbonyl, 5-membered aza-heteroaryl, or the group -CH2-OR3, -CH2-NR4R5 or -C (= 0) -NR4R6, and G2 is chloro, cyano, (C1-C4) -alkyl or - CR8AR8B-OH, -CH2-NR9R10, -C (= 0) -NR11R12 or -CH2-OR15, having tyrosine protein kinase inhibitory effects q, to processes for preparing such compounds, to pharmaceutical compositions containing such compounds, and the use of such compounds or compositions for treating neoplastic disorders, especially cancer diseases and tumor. |