abstract |
Provided is a compound useful as an inhibitor against the kinase activity of the EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of the EMLA-ALK fusion protein, the present inventors have found that the diamino heterocyclic carboxamide compounds of the present invention had an inhibitory effect on the kinase activity of the present invention. EML4-ALK. Through this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for the prevention and / or treatment of cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer. |