abstract |
The present invention relates to (R, S) 2-aryl-propionic acids and derivatives, their individual enantiomer (S), and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to deteriorated recruitment of polymorphonuclear neutrophils. (PMN leukocytes) at sites of inflammation. The present invention provides compounds for use in the treatment of transient cerebral ischemia, polymorphic pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis, and lesions caused by ischemia and reperfusion. |