| abstract |
The present invention relates to heteroaryl-cyclohexyl-tetraazabenzo [e] azulenes of formula (I), wherein R1, R2 and R3 are as described herein, in their manufacture, pharmaceutical compositions containing them and in their use as medicaments. The compounds according to the invention act as Via receptor modulators, and in particular as Via receptor antagonists. The active compounds of the present invention are useful as therapeutic agents that act peripherally and centrally in the treatment of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic cardiac insufficiency, inadequate secretion of nosepressin, nosopressin, nosopressin, nosocrin secretion, nosepressin, nosepressin, nosepressin, secretin autistic spectrum disorders, schizophrenia and aggressive behavior. |