| abstract |
The present invention is directed to low-toxicity boronated compounds and methods for their use in the treatment, imaging, and diagnosis of tumors. In particular, the present invention is directed to low-toxicity porphyrin compounds containing carborane with halide, amine, or nitro groups and methods for their use in particular in boron neutron capture therapy (BNCT), X-ray radiation therapy (X-ray therapy). ), and photodynamic therapy (PDT) for the treatment of brain, head and neck tumors, and the surrounding tissue. The invention is also directed to the use of these carborane-containing porphyrin compounds in tumor imaging and / or diagnostics such as MRI, SPECT, or PET. |