| abstract |
It is an object of the present invention to provide a medicament that is greatly improved in anti-tumor activity and excellent safety. According to the present invention, there is provided a medicament containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group -CH =, R1 represents a -ZR6 group, wherein Z represents a -CO-, -CH (OH) group or the like, R6 represents a 5-membered to 15-membered monocyclic, bicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 up to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom a halogen atom, Y represents a -O- group, a -CO- group, a -CH (OH) - or lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the such as p represents 1 or 2, R4 represents imidazolyl lower alkyl group or the like. |