| abstract |
The present invention relates to a pad comprising a layer containing a low hormone drug, such as gestodene, and optionally an estrogen (e.g., ethinyl estradiol). By administering the patch to a woman, plasma Gestodene levels of at least 1.0 ng / ml are achieved in solid state conditions without the need to incorporate penetration enhancers or permeation enhancers into the drug-containing layer. Conveniently, plasma hormone levels are also achieved over a period of at least 1 week, making the patch suitable for use in female contraception with the idea of administering the patch once a week. |