abstract |
The invention provides micromolecular drugs which are chemically modified by covalently attaching a water-soluble oligomer obtained from a monodispersed or two-soluble water-soluble oligomer composition. A conjugate of the invention, when administered by one of several modes of administration, exhibits a reduced rate of biological membrane passage compared to the rate of biological membrane passage of the micromolecule drug when not attached to the water soluble oligomer. |