| abstract |
Processes are provided for the preparation of 4 - [[4 - [[4- (2-cyanoethenyl) -2,6-dimethylphenyl] amino] -2-pyrimidinyl] amino] benzonitrile of formula (I), an N-oxide, a a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof, said processes comprising (a) the reaction of 4- (2-cyanoethenyl) -2,6-dimethylbenzenamine with an intermediate of formula (III) (b) the reaction of an intermediate of formula (IV) with acrylonitrile in the presence of an appropriate solvent; a palladium catalyst, a suitable base and a suitable solvent; (c) the dehydration of the corresponding amide of the compound of formula (I). |