| abstract |
The invention relates to a form of administration for the controlled release of the active substance 3- (2-dimethylaminomethylcyclohexyl) phenol, preferably (1R, 2R) -3- (2-dimethylaminomethylcyclohexyl) phenol, or one of the medicaments. which, (i) in vivo after 2 to 10 h reaches the peak plasma level of the active substance, and / or (ii) in vitro, measured in accordance with the European Pharmaceutical Paper with a buffer shaker in a pH of 6.8 (preferably 900 ml), a temperature of 37 ° C and 75 rpm. releases: after 0.5 hours 3.0 to 37% by weight, after 1 hour 5.0 to 56% by weight, after 2 hours 10 to 77% by weight, after 3 hours hours 15 to 88% by weight, after 6 hours at least 30% by weight, after 12 hours at least 50% by weight, after 18 hours at least 70% by weight. and after 24 hours at least 80% w / w. originally contained in the form of administration of the active substance. |