| abstract |
The invention relates to alkaloid reaction products obtained in a process in which alkaloids are reacted with an alkylating agent, preferably thiotepa, and then the unreacted alkylating agent and other water soluble compounds are removed from the reaction mixture by rinsing with water or a suitable solvent. the reaction mixture is treated with strong acid, preferably hydrogen chloride (HCl) to precipitate a water-soluble salt of the reaction products. The precipitated reaction products include at least one quaternary alkaloid derivative and are suitable as drugs for prophylactic or therapeutic application, particularly in the treatment of immune or metabolic dysfunctions and cancer. |