| abstract |
The present invention discloses novel compounds of Formula I: (I) having antagonistic activity against type I-β-HSD I, as well as methods for preparing compounds of this kind. In another embodiment, the invention discloses pharmaceutical compositions containing compounds of Formula I, as well as methods of using the compounds and compositions in the treatment of diabetes, hyperglycaemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with its activity. Type 11-β-HSD. |