| abstract |
The invention relates to derivatives of 1,2,3,4-tetrahydropyrrolo- [1,2-a] -pyrazin-6-carboxamide and 2,3,4,5-tetrahydropyrrolo- [1,2-a] [1, 4] -diazepine-7-carboxamides of general formula (I), in which R1 represents a hydrogen atom, a (C1-C10) alkyl, (C3-C7) cycloalkyl, (CH2) n - (C1-) group. C6) alkenyl, (CH2) n - (C1-C6) alkynyl, (C1-C6) alkyl-Z- (C1-C6) alkyl, where Z represents a heteroatom selected from O, N and S (O) m , or R1 represents a group of COOR, S (O) m R, an aryl or aralkyl; R2 represents one or more groups selected from a hydrogen atom of a halogen atom, a (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) alkenyl, (C1-C6) alkynyl, (C1-C6) alkyl-Z- (C1-C6) group alkyl, where Z represents a heteroatom selected from O, N and S (O) m, or R2 represents a halo (C1-C6) alkyl, halo (C1-C6) alkoxy, hydroxy, (C1-C6) group alkoxy, nitro, cyano, amino, a group NR7R8, COOR, C (O) NR7R8, O-C (O) (C1-C6) alkyl, S (O) m-NR7R8, an aryl group, R3 represents a group trifluoromethyl; R4 and R5 represent, independently of one another, a hydrogen atom, or R4 and R5 form together with the carbon atom bearing a saturate a circle containing from 3 to 6 carbon atoms and possibly containing from 0 to 1 heteroatom selected from O, N or S˙; R6 represents a group selected from a hydrogen atom, a halogen atom, a group (C1-C6) alkyl, (C3-C7) cycloalkyl, nitro, amino, a group NR7R8, COOR, an aryl group, a group NR7 (SO2) R8 or C (O) NR7R8; W represents a methylene or C (O) group; m represents an integer between 0 and 2, n represents an integer between 1 and 6, p represents an integer selected between 2 or 3. Preparation process and application in treatment. |