| abstract |
The pleuromutilin derivatives in which the glycolic ester moiety at position 14 has been replaced by R2 (CH2) mX (CH2) nCH2COO are used in antimicrobial therapy. In which: each of n and m is independently 0, 1 or 2, X is selected from -O-, -S-, -S (O) -, -SO2-, -CO.O-, -NH-, -CONH-, -NHCO-NH- and a bond, R1 is vinyl or ethyl, R2 is a non-aromatic monocyclic or bicyclic group containing one or two basic nitrogen atoms and bonded via a ring carbon atom, R3 is H or OH, or the R2 (CH2) mX (CH2) nCH2COO moiety at position 14 of (IA) or (IB) is replaced by RaRbC = CHCOO in which one of Ra and Rb is hydrogen and the other is R2 or Ra and Rb together form R2, or a pharmaceutically acceptable salt thereof. |