abstract |
The present invention relates to novel P2X7 inhibitors of formula (I) and to methods for their preparation, to intermediates useful for their preparation, to pharmaceutical compositions containing them, and to their use in therapeutics. The active compounds of the present invention are potent inhibitors of P2X7 and as such are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemic stroke or other autoimmune stroke, . |