| abstract |
The invention relates to novel compounds which are derivatives of the 3-phenylpropionic acid of formula I wherein W represents the COOH group or its bio-esters, or the -COO-C1-C4-alkyl group; Y represents NH, N -C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C1 - C10-alkyl, N-aryl, NSO2-C1-C10-alkyl, N-SO2-aryl, or N-SO2-heteroaryl; R1 to R8 each represent independently a hydrogen atom or a substituent specified in the specification; is as defined in cont writing; n represents an integer from 0 to 4, including; and their pharmaceutically acceptable salts. The compounds are the PPAR gamma receptor ligands and are useful as drugs. |