| abstract |
The present invention relates to the production of a compound as a product having the structure according to the formulas IA and / or IB wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen or when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is COOH or COOR4; R4 is an alkyl or aryl moiety; A, B and D are their ring substituents each of which can et be different or the same and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy and alkoxy. This method comprises incubating a starting compound having a structure according to formulas IIA and / or IIB in which R3 is -CH3 and R1, R2, A, B and D are defined above. In the presence of a micro-organism under conditions effective for the production of the compound compound. The microorganism may be of the genera Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacter. Alternatively, the microorganism may be Cunninghamella bainieri. |