| abstract |
The present invention includes novel carrier or excipient systems and oral pharmaceutical compositions containing as active ingredient Raloxifene, Amoxifene, Droloxifene, Arzoxifene or CP 336156, or a compound thereof, of the formulas (I) or (II), wherein Z is a group selected from the formulas (a, b or c), wherein: R 1 is selected from H, OH or its C 1 -C 12 esters or alkyl ethers, benzyloxy or halogen; or C 1 -C 4 halogenated ethers; R 2 , R3, R4, R5 and R6 are H, OH or C1-C12 esters or alkyl ethers thereof, halogen or C1-C4 halogenated ethers, cyano, C1-C6 alkyl or CF3, provided that, when R1 is H, R2 is not OH; Y is the group of formula (d), wherein R7 and R8 are alkyl or are linked between to form an optionally substituted nitrogen-containing ring or a pharmaceutically acceptable salt thereof and excipients, selected from pharmaceutical fillers, slides, lubricants, wetting agents and antioxidants. |