| abstract |
A hydrophilic matrix is disclosed, which contains: a) at least one polyacrylic acid derivative in preferred amounts of 0.5-40%, b) at least one cellulose ether in preferred amounts of 30-90%, and c) at least one disintegrant in preferred amounts of 2-50. %, by weight of the uterus. The matrix is used in combination with at least one pharmaceutically acceptable active substance to produce solid bioadhesive controlled release compositions for the treatment of vaginal diseases such as idiopathic candidiasis, bacterial colitis or trichomoniasis. The matrix is used in solid compositions in amounts of about 5-60%, preferably 20-40%, and the active substance in amounts of about 2-70%, preferably 5-50% by weight of the composition. |