| abstract |
The object of the invention is an oil-in-water booster emulsion containing at least: squalene, an aqueous solvent, a non-ionic hydrophilic surfactant which is a polyoxyethylene alkyl ether, a non-ionic hydrophobic, heat-retardant surfactant and 90% of the population of oil droplets has a size of less than 200 nm. The invention also relates to a method of preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, characterized in that the oil-in-water emulsion is obtained by a temperature-reversed phase method. |