| abstract |
Compound corresponding to general formula (I): where m denotes an integer equal to 1 or 2, R1 denotes an aryl or heteroaryl group optionally substituted by one or more groups R3 or R4, R2 denotes a group of general formula CHR5CONHR6, R3 denotes a halogen atom or a hydroxy group, cyano, nitro, C1-6 -alkyl, C1-6 -alkoxy, C1-6-thioalkyl, C1-6-fluoroalkyl, C1-6-fluoroalkoxy, - (C2-3 -alkylene) -, - O - (C1-3-alkylene) -O-, C1-6-fluorothioalkyl, C3-7 -cycloalkyl, C3-7 -cycloalkyl-C1-3-alkylene, piperidinyl, benzyloxy , pepper vinyl, pyrrolidinyl, morpholinyl, phenyloxy, NR7R8, NHCOR7, NHSO2R7, COR7, CO2R7, CONR7R8, SO2R7 or SO2NR7R8, R4 denotes an aryl or heteroaryl group, with R or R groups being optionally substituted with R or groups identical or different from one another, R5 denotes a hydrogen atom or a C1-3 -alkyl group, R6 denotes a hydrogen or a C1-6 -alkyl, C3-7-cycloalkyl or C3-7-cycloalkyl - C1-3 -alkylene, R7 and R8 denote, independently of one another, a hydrogen atom, a C1-3 -alkyl group or a phenyl group, the base or acid addition salt, hydrate or solvent constituent. The compounds are inhibitors of the FAAH enzyme which are useful for the treatment of pain, eating disorders, neurological and psychiatric pathologies, etc. |