| abstract |
<p> Phosphate-derived compounds of 1,2,3,4-tetraisoquinoline amide phenyl of formula (I): </p> <p> SPACE FOR FORMULA </p> <p> The preparation method comprises a reaction of Heck, between two compounds, to form another compound, whose aldehyde is oxidized, is peptically coupled to the compound of formula (VI) forming a compound whose ester is hydrolyzed, forms the corresponding carboxylic acid or carboxylate, becomes an acid derivative, It is coupled with an NHR3R4 amine, reacts with a phosphate derivative and hydrolyzed or hydrogenolized. Said compounds possess much higher solubility than the compounds of formula (I '), which inhibit antiapoptosis caused by Bcl-2 proteins, so they are useful against chemo or radioresistant cancers, malignant hemopathies and small cell lung cancer. </ p> |