| abstract |
The invention relates to quinoline and quinoxaline derivatives as protein tyrosine kinase inhibitors of the formulas: [5- (4-Ethyl-piperazin-1-yl-methyl) -pyridin-2-yl] -amide of acid 8- (2,6-Difluoro-2,5-dimethoxy-phenyl) -quinoxalin-5-carboxylic acid; 8- (2,6-Difluoro-2,5-dimethoxy-phenyl) -quinoxalin-5-carboxylic acid (4-dimethyl-amino-methyl-1H-imidazol-2-yl) -amide; 8- (2-Chloro-6-fluoro-3,5-dimethoxy-phenyl) -quinoxalin-5- (4-methyl-piperazin-1-yl-methyl) -pyridin-2-yl] -amide 8 - (2-Chloro-6-fluoro-3,5-dimethoxy-phenyl) -quinoxalin-5-carboxylic acid (5-piperazin-1-methyl-pyridin-2-yl) -amide. In particular for the treatment of diseases mediated by protein tyrosine kinase, such as cancer. |