http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CU-22858-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c7017a5e38bd3e417fa90c2a8a43ee7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-04 |
| filingDate | 1998-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f69d031e88c181f90e19f1438e071ac9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e7aaf78dc2ac1a36c7a48c09d73906e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0af3bca8c36d47831caf4a965d261050 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67d99df3fc9ae5b9261acbcac3d042a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73213528b6f6ab540d108b0515fe68ad |
| publicationDate | 2003-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CU-22858-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING SUBSTITUTED N-ALENIL ACRIDONS |
| abstract | This invention is related to the field of organic synthesis and aims to develop a process for obtaining substituted n-alenyl acridones of the general formula: In which R1, R2, R3, R4, R5, R6, R7 and R8 is a hydrogen or halogen atom or a nitro, amino, alkyl, trichloromethyl, trifluoromethyl, alkoxy, alkylamino, acetamido, aryloxy, cyano, hydroxyl group, and R0 is an alenyl group. Acridones are a family of heterocyclic compounds that have three rings fused together, which characterize their base structure. Recently there has been a development in the biological investigations of this family, proving that some derivatives have antiallergic, antiviral, antitumor activity. Given the importance of its biological properties, the present invention provides a new method for obtaining N-alenyl derivatives of acridones that allow improving solubility as well as performing other chemical transformations in its structure. The alkylation of the acridones was carried out with the use of catalysis by liquid-liquid phase transfer using quaternary ammonium salts as the reaction catalyst. As a product of the alkylation with propargyl bromide, an R-CH2-C-CH structure is not obtained as expected, but an accumulation of accumulated dienes R-CH = C = CH2 which is demonstrated by spectroscopic methods. We are not aware that these derivatives have been obtained under the reaction conditions described in this invention. |
| priorityDate | 1998-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.