| abstract |
The invention relates to aryl ether compounds of Formula I SPACE FOR FORMULA I or a pharmaceutically acceptable salt thereof prepared from an inorganic base, organic base, inorganic base, organic base, inorganic acid or organic acid, where: R1 it is aryl or heteroaryl; R2 is nitro, carboxaldehyde, carboxylic acid, ester, amido, cyano, halo, sulfonyl, alkyl or heteroalkyl; R3 is hydrogen, halo, cyano, alkyl, heteroalkyl, alkenyl, alkynyl, alkylamino, carboxaldehyde, carboxylic acid, oxime, ester, amido or acyl, or R2 / R3 and the atoms to which they are attached form a carbocycle of 5 or 6 members with at least one Sp3 hydride carbon; R4 is nitro, halo, cyano, alkyl, sulfinyl, sulfonamide, sulfonyl or sulfoximinyl; and R5 is hydrogen, halo or alkyl wherein said compounds of formula I are capable of modulating the activity of HIF-2alpha involved in some cancer diseases and are useful for treating renal cell cancer. The invention also provides a pharmaceutical composition containing said compounds of formula I, which is useful for treating renal cell carcinoma. |