| abstract |
The present invention relates to chemistry, pharmaceuticals and in particular to obtaining new molecular entities, tricyclic and tetracyclic derivatives of the benzodiazepine, pyridodiazepine and pyrimidodiazepine type fused to 1,4-dihydropyridine derivatives, with action on the central nervous system and vascular. From derivatives containing a dihydropyridine ring, through reactions with compounds of the ortho-phenylenediamines, ortho-diaminopyridines and ortho-diaminopyrimidines, as well as subsequent transformations to some of them, tricyclic and tetracyclic derivatives of general formula I-XII are obtained containing a diazepine or diazepinone nucleus fused to a 1,4-dihydropyridine core, where cycle A is a benzene, pyridine or pyrimidine ring substituted or not. These molecular entities have a GABAergic and modulating action on calcium channels, which can be used in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological diseases. FORMULA SPACE |