| abstract |
This invention relates to the branch of chemistry, in particular with the field of organic synthesis of compounds belonging to the category of bicyclic or naphthalene aromatics, used in the detection of amyloid plaques. These new naphthalene derivatives have a general formula: SPACE FOR FORMULA Where R represents independent groups from each other. In I: R1: -alkylene-C (O) NH-alkylene-R3, -alkylene-C (O) O-R4; R3: -COOH, -OH, -SH, -NH2, -alkyl-NH, -alkyl-N-dithiocarbamate of alkaline earth metal salts; R4: H, succinimide group; R2: -H, -alkyl. In II: R1: -alkyl, -alkylene-halide, -alkyl-hydroxy, -alkylene-O-arylsulfonate, alkylene-O-alkylsulfonate; R2: halide, -alkylene-O-arylsulfonate, -alkylene-O-alkylsulfonate, -alkylene-halide, -CH (O), -HC = CHNO2, -alkylene-NH2, -alkylene-NH-alkyl, -alkylene-alkyl -N-alkaline salts dithiocarbamate. The terms "alkyl" and "alkylenyl" refer to linear or branched aliphatic chains, preferably 1 to 4 carbon atoms and the term halide to Fluorine, Bromine or Iodine. These compounds are neutral, lipophilic and of low molecular weight and therefore cross the blood brain barrier and adhere to the amyloid plaques. The present invention provides the processes for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger scale manufacturing. We are not aware that the compounds presented in this invention have been reported previously. |