abstract |
The present invention relates to novel cyclosporin A derivativesnwith the immunosuppressive effect they havena functional group that can be attachedncyclosporine backbone. These are derivativesnformulas: rQ-o6-Abu-Sar-MeLeu-Val-MeLeuAla- (D) -Ala-MeLeu-MeLeu-MeValinwhere Q stands forneither (2S, 3R, 4R) -3-hydroxy-4,7-dimethyl-2-methylamino-8-oxo-octanoic acidnacid, orn(2S, 3R, 4R) -3-Hydroxy-4-methyl-2-methylamineno-9-oxo-nonanoic acid. |