http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-277165-B6
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1bbccc7e5208f370ed47280e88be4af |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-64 |
| filingDate | 1991-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_424542635f1909f5ff12b0a2a81832a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e58929ee892e1139d8c049208da9283a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_222714e0da876484b0d6b642c31f640f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_916dabea48a9616ed34b579f6652aac6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2918214305c1b013f2293c376633994 |
| publicationDate | 1992-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-277165-B6 |
| titleOfInvention | 1,4-dihydropyridine-3,5-dicarboxylic acid esters and their preparation |
| abstract | The solution is the novel 1,4-dihydropyridine-3,5-dicarboxylic acid estersnwith effects onncardiovascular system of general formulanWherein X is nitronin the 2 'or 3' position, chloro and bromonin position 2 'or 3 * 1 and R 1 represents alkylnC-to-C4 may be branched or unsaturatednalkyl C3 or methoxyethylnor is identical to R2 and R2 is substitutedn1,3-dioxolane groupnof formula II in which R3 and R4 representntwo methyl or polymethylene groupn(CH 2) n wherein n = 4 to 7. Synthesizedncompounds in in vivo animal testsnand exhibited potent antihypertensive activity in in vitro assaysneffect and effect on cerebrovascularnsystem. Process for preparing compoundsnof the formula (I) is that it isnthe substituted benzaldehyde is reactednwith este: ·; acetoacetic acid and estern3-aminocrotonic acid in the mediumnof an inert solvent at 20-150 ° Cnin the presence of catalysts. Because he'snthe substituted ester is reactedn2- (X-benzylidene) -3-ketocarboxylic acidnwith a 3-aminocrotonic acid esternthe above conditions. |
| priorityDate | 1991-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.