http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-271571-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff27d8bf75a1910ff2c67799799899e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8095fcbc14f32f140efa46074f127f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9605fba43df6fee201903430f71659b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_99341dd4245140062abf6bca5f534629 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe6746c6bb05a47806c6b62f20a40880 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1987-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57eb594cb8f5c584b036dd2298ffca6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea78debb90ef5e2cceb38a3aeca26a53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20f8cab691fdc3c7cae187892c326fff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c08cc20affd15870e856304e7fb8c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2f9b7e650b0f3accf63d82fa1e5eb5 |
| publicationDate | 1990-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-271571-B1 |
| titleOfInvention | Piperazine derivatives, their salts and method of their preparation |
| abstract | Pharmaceutically active piperazine derivatives, particularly piperazines substituted in position 1 with a 2-(2-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yloxy)ethyl residue and in position 4 a hydrogen atom or a methyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-(aminocarbonyl)ethyl, 2-(acetoxy)ethyl or 2 (decanoyloxy)ethyl group, their acid addition salts and processes for the preparation thereof. The compounds are noncataleptic neuroleptics with high affinity to dopamine D-2 receptors and with in vivo antidopaminergic activity but only slight sedative, adrenolytic and anticholinergic properties; but use as antipsychotic drugs free of undesirable side effects. Said compounds are available by several routes, such as (a) reaction of 10-(2-bromo-ethoxy)-2-chloro-10,11-dihydrodibenzo(b,f)thiepin with piperazine, 1-methylpiperazine, 2-(1-piperazinyl)ethanol, or 3-(1 piperazinyl)propanol and (b) acylation of aminoalcohols obtained by the preceding method with chlorides of the corresponding aliphatic carboxylic acids. Preferred addition salts are succinates, maleates, hydrochlorides and methanesulphonates prepared by the respective neutralization reactions. |
| priorityDate | 1987-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.