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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P29-00
filingDate 1986-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ef735b97a1e423d843e6ed57c74ec8c
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publicationDate 1990-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CS-267807-B1
titleOfInvention A method for culturing a production strain of Streptomyces aureofaciens for producing chlortetracycline
abstract The solution is to optimize conditionsnculturing the Streptomyces production strainnaureofaciens and ehlortetracycline biosynthesis.nThe proposed procedure will be achievednproductionnthe media is released from the corn extractnmore amino acids, especially basic amino acids,nwhich diminishes the dimensionless valuenC: N ratio at the beginning of growthnphase. By developing a dosing regimenneasily accessible carbohydrate sourcenthe activity is increasednof secondary metabolism enzymes. Surfacensucrose is regulated between 30nup to 50 h, preferably 30 and 35 h onnconcentration of 35 mg.ml with its spontaneousnfollowed by a decrease to 15 ton, 22 mg.ml in the period between 45 and 50 h of culturenwhile maintaining the levelnof ions between 0.35 and 0.45 mg.mlnThe solution is to accelerate kineticsnabout 5% of the production of chlortetracycline \ tnand extending the linear gain effectivenup to 130 h. Except absolutenincreasing the content of chlortetracyclinenin the fermented soil is achievednmaterial and energy savingsncosts.
priorityDate 1986-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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