http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CS-266851-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb98df3b2dd2de0acdd00784c1c8c3ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e7f9bf224938bb1fdeb76329b7a678e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-08 |
| filingDate | 1985-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2534d262061fd4fbd4ffd059a6d3da5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b19eb1c418cfbc62275cce8b11949552 |
| publicationDate | 1990-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CS-266851-B1 |
| titleOfInvention | Heparin sorbent and substances containing heparin structures and method for their preparation |
| abstract | Heparin sorbent and substances containingnheparin structures, protein-heparin complexesnand other anionic substances whose naturenIt is based on the hydrophilic macroporousnthree-dimensional copolymers of hydroxyalkyl acrylates,noptionally hydroxyalkyl methacrylatesnwith alkylenediacrylates or alkylenedimethacrylatesnprotamine sulphate, protamine chloride,npoly-L-lysine or another oligopeptide and polypeptidencontaining predominantly arginine, histidinenand lysine. Immobilization is covalentnby binding the polypeptide to activated hydroxyalkyl acrylatenor hydroxyalkyl methacrylatencarriers. These copolymer carriers are activatednby reaction with epichlorohydrin and the product of this reactionnallowed to react with the polypeptide solutionnin buffer pH 8-12 containingn1.5 to 1.8 mol / l ammonium sulfate at 10 ° Cnto 45 ° C for 10 to 100 hours. After endingnthe reaction is possibly unreacted epoxyngroups are allowed to spontaneously hydrolyze.nThe protamine molecules are removed by affinityneluting with heparin solution. Sorbents drynthey are used in separation technology and technologynboth analytical and preparative. |
| priorityDate | 1985-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.